Treatment-Resistant Depression: A Narrative & Systematic Review Of Definitions & Methods In Clinical Research Studies

On December 19, 2016, the Agency for Healthcare Research and Quality (AHRQ) released this document regarding treatment-resistant depression (TRD). The goal of the document is to provide a narrative and systematic review of definitions and methods in clinical research studies; review and inform the definition of TRD in clinical research; obtain information on the use of the definition of TRD in the context of coverage with evidence development and treatment outcomes; and comprehensively examine the study design issues affecting both outcomes and bias in the study of TRD . . .