District of Columbia's Patient-Centered Outcomes Research Institute (PCORI) announces the availability of funding for implementation of the Pragmatic Clinical Studies and Large Simple Trials to Evaluate Patient-Centered Outcomes Grant. PCORI seeks to fund investigator-initiated large pragmatic clinical trials, large simple trials, or large-scale observational studies that will involve representative patient populations; have strong endorsement and study participation by relevant patient organizations, professional organizations, and/or payer or purchaser organizations; take place within typical clinical care and community settings; and have a sample large enough to allow precise estimates of effect sizes and support evaluation of . . .