Evaluating Clinical Significance of Treatment Outcomes in Studies of Resistant Major Depression

May 2008 The researchers evaluated the results of two clinical trials involving 164 patients with unipolar non-psychotic major depressive disorder who did not receive adequate benefit from one previous treatment at or above the minimal effective dose and duration. The first trial was a four-to-six week randomized, placebo-controlled, double-blind, monotherapy study of Transcranial Magnetic Stimulation (TMS). Patients who did not respond to therapy in the first study were entered into a second six-week, open-label TMS monotherapy trial. The research was conducted to assess the effectiveness of the Neuronetics NeuroStar TMS device to determine . . .