Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression

January 24, 2007 Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression Commonly prescribed antidepressants are similar in effectiveness to each other but differ when it comes to possible side effects, according to an analysis conducted by the federal Agency for Health Care Research and Quality. The findings, based on a review of nearly 300 published studies of second-generation antidepressants, show that about six in ten (60%) adult patients get some relief from the drugs. The same percentage (60%) also experience at least one side effect, ranging from nausea to sexual dysfunction. Patients who don . . .