CATIE Schizophrenia, Statistical Methods for The Primary Analysis, In The Form of an Updated Methods Section From The Protocol

October 3, 2005 CATIE Schizophrenia, Statistical Methods for The Primary Analysis, In The Form of an Updated Methods Section From The Protocol The primary objective of the CATIE trial was updated during the course of the trial and prior to the completion of data collection. The original primary hypothesis, specified in 1999, was that the three atypical antipsychotics, pooled together, would be superior to perphenazine, the conventional antipsychotic treatment. The second step of the primary analysis was to compare the three atypical antipsychotics to each other, given that they were together found to be superior to perphenazine. Analyses presented in . . .