Mood Stabilisers Plus Risperidone or Placebo In The Treatment of Acute Mania

October 17, 2005 Mood Stabilisers Plus Risperidone or Placebo In The Treatment of Acute ManiaResults: Young Mania Rating Scale (YMRS) scores improved rapidly with significantly greater reductions at week 1 in the risperidone group compared with the placebo group. At end-point YMRS scores decreased by 14.5 and 10.3 points in the risperidone and placebo groups, respectively. Significant improvements v. placebo (P<0.05) were noted in the risperidone group on several other clinically meaningful measures.Additionally, a post hoc analysis excluding carbamazepoine-treated patients (plasma concentrations of risperidone active moiety were 40% lower in this group . . .