Treatment In The Fentanyl Era 

What drug is the leading cause of overdose deaths in the U.S.? Fentanyl has had that distinction since 2017.

According to a new analysis—Drugs Most Frequently Involved In Drug Overdose Deaths: United States, 2017–2023—since 2017, fentanyl has been the leading cause of overdose deaths in the U.S., over 73,000 per year in 2022 and 2023. This represents 69% of overdose deaths in 2023.

In addition, fentanyl was the most common concomitant substance found in overdoses due to other drugs, ranging from 99.0% of xylazine-involved drug overdose deaths to 48.3% of oxycodone . . .