The Denver Psilocybin Mushroom Policy Review Panel issued its report on the impact of psilocybin mushroom decriminalization as it pertains to the public safety, public administration, public health, and fiscal impacts to the city and county of Denver. In May 2019, the city decriminalized personal possession, cultivation, and storage of psilocybin mushrooms. The Panel reported that there has been no major increase in arrests related to the distribution of psilocybin mushrooms and no major cartel elements or organized crime. Most individuals using psilocybin mushrooms used them for self-exploration and mental health, according to preliminary university level observational research.

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