Alzheimer’s Presenting With Memory Problems Has Slower Decline Rate Than Alzheimer’s With Language Difficulties Or Judgment Changes

People with Alzheimer’s Disease (AD) whose initial symptoms were language difficulties or judgment changes had a faster rate of decline than people who had memory problems as their initial symptoms. When compared using a linear mixed model, those with language difficulties had the fastest rate of cognitive and functional decline.
The predominant initial cognitive symptom was assessed clinically, and decline was assessed cognitive and functional decline using the Clinical Dementia Rating-Sum of Boxes (CDR-SB). Overall, dementia from AD, Lewy body dementia (LBD) and mixed AD+LBD, presenting with initial non-amnestic cognitive symptoms was associated with faster . . .