Chronic Kidney Disease Severity Linked To Higher Risk Of Cognitive Impairment

As chronic kidney disease (CKD) advances, the prevalence of cognitive impairment—including problems with attention, processing speed, and executive function—increases, according to a recent study. Among those with CKD, higher urine protein-to-creatinine ratios (UPCR) were associated with cognitive impairments. However, lower estimated glomerular filtration rate (eGFR) alone was not associated with overall cognitive impairment. The combination of a higher UPCR and a lower eGFR was associated with impairments in global cognition.

The association was identified in a cohort study of 5,607 participants with CKD who were enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from . . .