Depression Among People With CKD Associated With Higher Triglyceride-Glucose Index Scores

American adults with chronic kidney disease (CKD) and symptoms of depression had higher scores on the triglyceride-glucose (TyG) index. The TyG index is a calculated value that estimates insulin resistance based on fasting triglyceride and glucose levels; it is a marker of cardiovascular disease risk and a higher index indicates higher risk. Among those with depression, the average TyG index was 8.69. Among those without depression, the average TyG index was 8.55.

Each unit increase in the TyG index corresponded to a 24% higher risk of depression. Compared to the risk of depression among those with the . . .