Therapies For Alzheimer’s Ineffective For ‘LATE-NC’ Dementia

Therapies that may work for dementia due to Alzheimer’s disease will probably not work for a form of dementia called “limbic-predominant age-related TDP-43 encephalopathy neuropathologic change” (LATE-NC), according to an analysis of more than 6,000 brains. The researchers found the LATE-NC-affected brain looks different from the Alzheimer's brain. About 33% of older adults have brain changes due to  Symptoms of LATE-NC mimic Alzheimer’s disease by causing memory loss and problems with thinking and reasoning in old age.

LATE-NC was first classified in 2019. In the brain analysis, about . . .