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The Department of Health and Human Services (HHS) is continuing its pursuit of the use of artificial intelligence (AI) to improve clinical care and lower health care costs with the release of a request for information (RFI) on December 19, 2025.

HHS seeks comments on ways to integrate AI in care delivery and create new, long-term market opportunities that improve health and well-being, including public-private partnerships and cooperative research and development agreements. Responses are due by February 23, 2026.

The RFI seeks feedback on how HHS could use its regulatory, reimbursement, and research and development levers across . . .

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