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A worldwide study of the link between cardiovascular disease (CVD) and depression symptoms found that middle-aged adults with four or more depressive symptoms had more cardiovascular events and greater risk of death than people without depressive symptoms. The relative risk of a cardiovascular event or death was twice as high for people in urban areas compared to people in rural areas.

Having four or more depressive symptoms was associated the following, compared to people without depressive symptoms:

14% higher likelihood of having CVD
17% higher risk of death from any cause
18% higher risk of CVD and death
23 . . .

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