The annual medical cost associated with a principal or secondary diagnosis of addiction disorder in U.S. emergency departments and inpatient settings totaled approximately $13.2 billion in 2017, representing 0.38% of the total $3.49 trillion U.S. health care expenditure for 2017. Annual acute medical costs were defined as hospital facility charges (actual expenses incurred in the production of hospital services, such as wages, supplies, and utilities), and professional fees, depending on payer, not related to treating the addictive disorder. For 2015, OPEN MINDS estimated that total spending for addiction treatment across all settings and . . .